| Date | Player | Injury (Status) |
|---|---|---|
| 08/13/2018 | Jamal Carter | Hamstring (Injured Reserve) |
| 08/09/2018 | Troy Fumagalli | Groin (Injured Reserve) |
| 08/29/2018 | Jerrol Garcia-Williams | Torn ACL, Left Knee (Injured Reserve) |
| 09/04/2018 | Deiontrez Mount | Achilles (Injured Reserve) |
| 02/07/2018 | Jordan Taylor | Hip (PUP) |
| 09/27/2018 | Jake Butt | Torn ACL (Injured Reserve) |
| 10/15/2018 | Ron Leary | Torn Achilles Tendon (Out for Season) |
| 11/02/2018 | Brandon Marshall | Knee |
| 11/05/2018 | Matt Paradis | Fractured Left Fibula (Injured Reserve) |
| 11/16/2018 | Max Garcia | Torn ACL (Injured Reserve) |
| 11/17/2018 | Dymonte Thomas | Ankle |
| 11/26/2018 | Jeff Heuerman | Ribs (Injured Reserve) |
| 11/26/2018 | Shaquil Barrett | Hip |
| 11/30/2018 | Tramaine Brock | Ribs |
| 12/05/2018 | Emmanuel Sanders | Ankle (Injured Reserve) |
| 12/08/2018 | Chris Harris Jr. | Fibula |