| Date | Player | Injury (Status) |
|---|---|---|
| 09/04/2018 | Jerick McKinnon | Torn ACL, Right Knee (Injured Reserve) |
| 09/02/2018 | JP Flynn | Knee (Injured Reserve) |
| 07/25/2018 | Kentavius Street | Torn ACL (PUP) |
| 09/12/2018 | Brock Coyle | Concussion (Injured Reserve) |
| 09/24/2018 | Jimmy Garoppolo | Torn ACL (Out for Season) |
| 10/22/2018 | Adrian Colbert | Sprained Ankle (Injured Reserve) |
| 11/01/2018 | Jaquiski Tartt | Shoulder |
| 11/02/2018 | Raheem Mostert | Broken Right Forearm (Out for Season) |
| 11/02/2018 | Emmanuel Moseley | Shoulder (Injured Reserve) |
| 11/10/2018 | Pierre Garcon | Knee |
| 11/24/2018 | Joshua Garnett | Thumb |
| 11/27/2018 | Jimmie Ward | Forearm (Injured Reserve) |
| 11/30/2018 | D.J. Reed Jr. | Heel |
| 12/04/2018 | Kyle Nelson | Suspension (10 Games) |
| 12/05/2018 | Dekoda Watson | Calf (Injured Reserve) |
| 12/08/2018 | Matt Breida | Ankle |