| Date | Player | Injury (Status) |
|---|---|---|
| 09/04/2018 | Jerick McKinnon | Torn ACL, Right Knee (Injured Reserve) |
| 09/02/2018 | JP Flynn | Knee (Injured Reserve) |
| 08/16/2018 | Marcell Harris | Hamstring (Injured Reserve) |
| 07/25/2018 | Kentavius Street | Torn ACL (PUP) |
| 09/08/2018 | Malcolm Smith | Hamstring |
| 09/08/2018 | Dekoda Watson | Hamstring (Injured Reserve) |
| 09/12/2018 | Brock Coyle | Concussion (Injured Reserve) |
| 09/15/2018 | Joshua Garnett | Toe |
| 09/15/2018 | Erik Magnuson | Hamstring |
| 09/24/2018 | Jimmy Garoppolo | Torn ACL (Out for Season) |
| 09/29/2018 | Jaquiski Tartt | Shoulder |
| 10/06/2018 | Dante Pettis | Knee |