The New England Patriots and Atlanta Falcons were left searching for answers after surprise losses to the Tennessee Titans and Cleveland Browns respectively.
In Nashville, Marcus Mariota passed for 228 yards and two touchdowns and running back Derrick Henry rushed for 58 yards and two scores as the Titans thumped the Patriots 34-10.
The Titans' defense sacked Tom Brady three times and held the high-scoring Pats offense to 284 total yards. The Patriots fell to 7-3, while the Titans are 5-4.
In Cleveland, Browns rookie running back Nick Chubb rushed for 176 yards, added 33 more through the air and scored twice as the Browns upset Atlanta 28-16. He also provided the highlight of the day with a 92-yard TD run, the longest in franchise history.
Elsewhere, the two Los Angeles teams faced challenges but prevailed. In Oakland, Chargers quarterback Philip Rivers did not have a completion until the second quarter, but once he and running back Melvin Gordon got rolling, LA won 20-6 to improve to 7-2.
The Rams, who had never lost back-to-back games in the Sean McVay era, were close to doing so on Sunday when they hosted the Seahawks. Seattle quarterback Russell Wilson tried to engineer one of his famous fourth-quarter comebacks but fell short, going four-and-out on the final drive. Los Angeles (9-1) claimed a 36-31 victory to solidify their spot atop the NFC West.
Patriots receiver Julian Edelman injured his ankle in the team's loss to the Titans. He exited the game early and never returned. Other New England players that were injured in the contest were offensive tackle Trent Brown (back) and tight end Dwayne Allen (knee).
New Orleans left tackle Terron Armstead left the Saints' matchup against the Bengals after sustaining a shoulder injury during the first half. He was then ruled out of the game.
Raiders wide receiver Martavis Bryant was ruled out with a knee injury. A later report stated Bryant suffered a possible PCL tear, and will have an MRI to determine the severity of the injury.
A number of Packers were injured as Green Bay hosted the Dolphins. Safety Kentrell Brice left the game with an ankle injury, linebacker Nick Perry suffered a new injury, and guard Lucas Patrick was evaluated for a concussion.
Bengals cornerback Dre Kirkpatrick was unable to finish the game against the Saints after suffering a concussion.
Miami cornerback Bobby McCain was ruled out of the game with a head injury. Team-mate and receiver Jakeem Grant was carted off to the locker room with a leg injury. Fellow receiver DeVante Parker suffered a shoulder injury.
Rams wideout Cooper Kupp suffered another knee injury against the Seahawks and did not return.
By the numbers
Chiefs QB Patrick Mahomes threw for his 31st touchdown against the Cardinals, setting the franchise record for most touchdown passes in a single season, breaking a mark set by Len Dawson in 1964.
Single-season touchdown record broken...in 10 games. pic.twitter.com/V9HOhEcnoR— Kansas City Chiefs (@Chiefs) November 11, 2018
Falcons receiver Julio Jones became the fastest player in NFL history to reach 10,000 receiving yards. He reached the milestone in his 104th game.
Drew Brees passed Brett Favre for second-most passing touchdowns in NFL history, breaking the Hall of Famer's mark of 508 with three first-half touchdown passes against the Bengals.
The Redskins suffered a big loss to the Falcons last week. This time around, Washington were not going to be on the losing end. Linebacker Ryan Anderson attributed the win to a sense of urgency: "We got our [expletives] kicked last week, so everybody had a sense of urgency. That's what playing good defense is about. We let them make some plays, they hit us on some stuff. So, we had to just come out and respond. Bend, but don't break."
The Bills thrashed the Jets 41-10, leaving New York receiver Jermaine Kearse and company frustrated: "Everybody's frustrated. I understand the fans are frustrated. We're frustrated. It's understandable. We're going to stick together. We're going to stick with Todd [Bowles, head coach]. We're going to have his back."
Week 10 NFL scores
Pittsburgh Steelers 52, Carolina Panthers 21
Washington Redskins 16, Tampa Bay Buccaneers 3
Kansas City Chiefs 26, Arizona Cardinals 14
Cleveland Browns 28, Atlanta Falcons 16
Buffalo Bills 41, New York Jets 10
Indianapolis Colts 29, Jacksonville Jaguars 26
Chicago Bears 34, Detroit Lions 22
New Orleans Saints 51, Cincinnati Bengals 14
Tennessee Titans 34, New England Patriots 10
Los Angeles Chargers 20, Oakland Raiders 6
Los Angeles Rams 36, Seattle Seahawks 31
Green Bay Packers 31, Miami Dolphins 12
Dallas Cowboys 27, Philadelphia Eagles 20
|Redskins QB Alex Smith released from hospital|
|Curry interviews retired NASA astronaut, apologises for moon comments|
|Lakers´ Stephenson to repeat air guitar despite technical|
|Fletcher pushed Miller on to Broncos sack record|
|The Sunday Seven - 7 Key Opta facts for NFL Week 15|
|It´s important to have his mentality - Mayfield thrilled with Kobe Bryant visit as Browns beat Bronc|
|Thunder´s Westbrook: ´When we defend like that — best team in the league´|
|Rallying Bulls stun Spurs, LeBron and Ball post triple-doubles|
|Mayfield leads Browns past Broncos|
|Lakers pair LeBron, Ball revel in triple-double feat|
|LeBron, Ball first Lakers team-mates with triple-doubles in same game since 1982|
|Hopkins´ two TDs help Texans close in on AFC South title with win over Jets|
|Dickerson hoping Barkley falls short of breaking his records|
|LeBron: Meeting Jordan for first time was godly|
|Curry reacts to Kings´ trolling with moon landing video|
|Wentz ruled out of Rams clash|
|Sabres suspend forward Berglund for failing to report to the team|
|WATCH: Dellavedova dives into media table to rescue possession|
|Kevin Durant provides playoffs warning to inconsistent Warriors|
|VanVleet turnover the ´turning point´ in Raptors loss|
|Shanahan on Mahomes no-look pass: ´I do it all the time´|
|´Fatigued´ Embiid has a lot on his shoulders - Brown|
|Westbrook on Murray scuffle: He was in my way|
|Injury-plagued Nuggets beat Thunder to hold Western Conference lead|
|Kings troll Curry by playing clips of moon landing|
|Ovechkin joins rare NHL club with second straight hat-trick|
|Athletics´ Chapman undergoes procedure on left shoulder|
|Beckham Jr. out of Titans clash|
|Pederson coy over Wentz back injury|
|Returning Nowitzki ´so tired´ after making NBA history|
|Hero Rivers feared he had cost Chargers in KC|
|Paul hails ´sick´ Harden after record-breaking display|
|Harden posts record fourth 50-point triple-double in win over Lakers|
|Chargers rally past Chiefs to clinch playoff spot|
|WATCH: Chargers top Chiefs on dramatic two-point conversion in final seconds|
|Suns owner Sarver committed to keeping team in Phoenix|
|Chargers WR Allen leaves with injury after near-spectacular catch|
|Cooper says Raiders owner wanted to trade him to Cowboys|
|Beckham continues to miss Giants practice with quad injury|
|Griffin hails ´phenomenal´ Lowry after Warriors demolition|
|Durant: Raptors are the real deal|
|Raptors upstage Warriors, Davis leads Pelicans with 44 points|
|Derrius Guice injury update: Redskins RB (knee) has rehab setback, undergoes 3 more procedures|
|Phillies sign McCutchen to three-year deal|
|O´Neal thinks his Lakers teams could ´easily´ beat Warriors|
|Curry says he was ´obviously joking´ about moon landing comments|
|Bologna´s winning start ended in BCL|
|Las Vegas to host 2020 NFL Draft|
|Jackson to remain Ravens´ starting QB despite Flacco return|
|Rams headline 2019 NFL International Series home teams|
|Rams headline International Series home teams for 2019|
|Clippers buckled under Raptors pressure - Rivers|
|Rockets make change, pick up win over Trail Blazers|
|Raptors star Leonard out against Clippers, may miss matchup with Warriors|
|Butler opens up about heated Timberwolves practice|
|Tenerife back to winning ways, AEK beat Hapoel|
|Butler´s groin strain ´nothing significant´ – 76ers coach Brown|
|Blue Jays release five-time All-Star Tulowitzki|
|Vikings fire OC DeFilippo after loss to Seahawks|
|We rallied around it - Durant on Green confrontation aftermath|
|He´s good at basketball – Kerr running out of superlatives for Curry|
|Green thrilled to make Warriors return in victory over Timberwolves|
|Fournette subjected to alleged racial abuse in Titans loss - Marrone|
|It´s the end of one of the best movies you could ever see - James pays tribute to retiring Wade|
|NASA invites Curry to see moon rocks|
|LeBron trumps Wade in last dance, Curry scores 38 points|
|Seahawks secure dominant win over Vikings|
|Drake makes plea for ball thrown into stands after Miami miracle|
|Yankees interested in Machado, not Harper - Cashman|
|Warriors´ Curry believes moon landing was faked|