The New Orleans Saints will be on a revenge mission when they do battle with the Los Angeles Rams on Sunday.
Los Angeles claimed a dramatic 26-23 overtime win over New Orleans in the NFC Championship game in January and they are set for an early-season battle nine months later.
Both sides got their seasons under way with victories and the Rams will have home advantage as they go in search of back-to-back successes.
The Green Bay Packers lock horns with the Minnesota Vikings, while the Seattle Seahawks travel to face the Pittsburgh Steelers.
We look at some of the key Opta facts for seven games on the second Sunday of the campaign.
“That’s how we work as a team!”— Los Angeles Rams (@RamsNFL) September 11, 2019
Starting off the 2019 season at 1-0! pic.twitter.com/n3H6MUDOEM
Dallas Cowboys @ Washington Redskins
The Cowboys have won five of the six games they have played against Washington since the start of the 2016 season, but the Redskins came out on top 20-17 at FedEx Field last season.
Washington went down 24-0 in their last home game of last season versus the Philadelphia Eagles, their fourth consecutive defeat in their own backyard.
Indianapolis Colts @ Tennessee Titans
The Colts have swept the Titans in all but one of the last seven seasons, with the exception being when Tennessee won both games in 2017.
Tennessee have won 75 per cent of their home games since the start of the 2017 season (12-4). Only five teams have a better home winning percentage in that time (New England, New Orleans, Kansas City, Philadelphia, Minnesota).
New England Patriots @ Miami Dolphins
Champions New England have lost 12 road games since the start of the 2014 season. A third of those losses have come in Miami, - 2014, 2015, 2017 and 2018.
The Dolphins have lost two straight home games, failing to score more than 10 points in either game. Patriots quarterback Tom Brady has thrown three or more touchdowns in nine regular season games against Miami, who shipped 59 points in their season-opening loss to the Baltimore Ravens.
Buffalo Bills @ New York Giants
The Giants have won four of the last five games versus the Bills, including each of the last three. However, the Bills have won on three of their last five visits to the Giants.
Since the start of last season, Bills quarterback Josh Allen has nine rushing touchdowns, three more than any other quarterback.
Seattle Seahawks @ Pittsburgh Steelers
The Steelers have won seven of the nine games played in Pittsburgh against the Seahawks, while Seattle have been shut out in their last two visits to Heinz Field.
Steelers quarterback Ben Roethlisberger failed to throw a touchdown pass in Week 1, snapping a streak of 26 consecutive games with a touchdown pass - the second-longest run in franchise history.
Minnesota Vikings @ Green Bay Packers
Minnesota have not lost to Green Bay in their last four matches, winning three. The Packers finished last season with a 31-0 home defeat at the hands of the Detroit Lions, but a vastly more competitive game will be expected against the Vikings with Green Bay quarterback Aaron Rodgers back to full fitness.
Vikings safety Anthony Harris had two interceptions against the Atlanta Falcons last week. He had three interceptions in his previous 51 NFL games.
New Orleans Saints @ Los Angeles Rams
The Rams were 7-1 at home last season, their best record since going 8-0 in 2003. They gained 3,620 yards at home last year, the fifth-most since 1940.
New Orleans wide receiver Michael Thomas had 10 receptions for 123 yards in Week 1. It was his 10th career game with 10 or more catches, the second most in the league since 2016 – Antonio Brown (11).
|Coronavirus: Massachusetts teams can re-open practice facilities, Celtics set to resume workouts|
|Cowboys´ Aldon Smith still feels great despite NFL layoff|
|Bengals QB Burrow and Dolphins coach Flores speak out on Floyd´s death|
|Coronavirus: NBA ´planning to restart season on July 31´|
|Reviewing the 2019-20 NHL regular season|
|Matthew Judon signs franchise tag to stay with Baltimore Ravens|
|Cardinals´ Hopkins: I´m the best wide receiver in the NFL|
|Eli Apple agrees terms with Panthers after failed Raiders move|
|NFL tables proposed fourth-and-15 onside-kick alternative|
|Coronavirus: MLB´s proposal for more salary cuts a non-starter – Scherzer|
|Browns QB Mayfield ready for ´big year´, but under no added pressure|
|Aaron Jones hoping to be ´lifelong Packer´|
|Coronavirus: Basketball Hall of Fame pushing enshrinement ceremony to 2021|
|Texans DE Watt says asking for extension would be ‘wrong move’|
|Sharks GM says Bob Boughner not guaranteed to return as coach|
|Rams CB Jalen Ramsey says he definitely will report to training camp|
|Coronavirus: NHL announces return-to-play format with 24-team playoff|
|Washington Wizards star John Wall says he is ´110 per cent´ healthy|
|Coronavirus: Lillard won´t play in shortened NBA season if Trail Blazers can´t make playoffs|
|Coronavirus: Dolphins owner Ross says NFL season will ‘definitely’ happen|
|Michael Jordan v LeBron James: How the NBA greats´ playoff numbers compare|
|´There´s a significant place for it´ – Coles´ Celtics embracing AI and data|
|Coronavirus: Tampa Bay Rays open Tropicana Field for limited workouts|
|Coronavirus: Ewing released from hospital and ´getting much better´|
|Coronavirus: NHL releases framework for players to return to club facilities|
|Coronavirus: EuroLeague season cancelled, no 2019-20 champions|
|On this day in sport: Ali wins controversial Liston rematch, Liverpool pull off Istanbul miracle|
|Andrew Bogut leaves Sydney Kings, not retired yet|
|The Match: Tiger and Manning hold off rallying Mickelson and Brady|
|The Match: Tom Brady holes out from fairway to stun Tiger and Manning|
|The Match: Manning goes one up on Brady with Belichick and Foles jibes|
|Coronavirus: New York governor says pro teams can resume training|
|Legendary college basketball coach Eddie Sutton dies at 84|
|Ex-NFL quarterback Leaf arrested on domestic charge|
|Coronavirus: NBA targeting late-July return at Disney campus|
|Coronavirus: Celtics preparing for NBA season to return|
|Coronavirus: NHLPA executive board approves NHL´s proposed return to play format|
|Cleveland Browns offering fans chance to call plays|
|Coronavirus: NBA Hall of Famer Ewing tests positive for COVID-19|
|Joe Flacco: Jets sign former Super Bowl MVP|
|Coronavirus: Russell Westbrook donates meals to healthcare workers|
|Jerry Sloan: ´The Original Bull´ produced iconic Jazz team to take on Michael Jordan|
|Tom Brady: QB does not want to ´be the almighty´ with Buccaneers|
|Legendary Utah Jazz coach Jerry Sloan dies aged 78|
|NHL, players considering 24-team conference-based playoff format|
|Chiefs CEO says Mahomes extension talks will begin this summer|
|Kraft´s Super Bowl LI ring sells for $1.025m|
|Giannis wants to smoke a cigar like Jordan and celebrate Bucks´ NBA title in Mykonos|
|Coronavirus: NFL games without fans ´wouldn´t be fun´, says Rams star Donald|
|Brady exit leaves AFC East ´wide open´ – Jets RB Gore|
|Dolphins QB Fitzpatrick eager to compete with, mentor Tagovailoa|
|ESPN to make Tom Brady documentary series|
|Ja Morant ´deserves´ Rookie of the Year over Zion Williamson|
|The Last Dance: ´I was not just playing Michael´ - Malone speaks about facing Jordan and the Bulls|
|Teaching Bucs offense to Tom Brady is ´weird´ – Brate|
|Pierce leaves LeBron out of his top five NBA players of all-time|
|Coronavirus: Lakers´ Dudley ´90 per cent confident´ of NBA returning|
|Tocchet confident Taylor Hall will consider re-signing with Coyotes|
|Steelers WR Ryan Switzer says Ben Roethlisberger throwing with ´no restraints´|
|NFL reinstates DE Aldon Smith after five-year absence|
|Browns WR Jarvis Landry says his hip rehab is ´ahead of schedule´|
|Coronavirus: Redskins WR Gandy-Golden says he´s recovered from positive test|
|New England Patriots hand veteran safety Patrick Chung two-year extension|
|The Last Dance: Michael Jordan branded a liar and ´snitch´ by Horace Grant|
|Rangers would prefer to hold second spring training at new stadium|
|Coronavirus: Nationals to receive World Series rings in virtual ceremony|
|Coronavirus: NFLPA president says COVID-19 isn´t ´going to kneel down to almighty football´|
|Coronavirus: NFL chief medical officer expects positive tests, unsure when players can attend facili|
|NFL announces changes to increase diversity|
|Tom Brady works out with new Buccaneers team-mates at Tampa prep school|